Chemistry Through Veterinary Medicine The Use of Acepromazine to Control Fear and Aggression in Dogs

My friend, Kathy, has a dog named Mollie, who is a 4-year-old "rescue dog" that weighs 60 lbs. And has the verified DNA of a Malamute/German Shepherd/Wolf mix. Mollie is literally a moody bitch: a female dog that is sometimes friendly and sometimes hostile. She can definitely frighten people because she looks like a wolf, complete with piercing eyes and long, sharp, gleaming fangs. On October 1st, Mollie was taken to her veterinarian's office for her scheduled Rabies vaccination. Unfortunately, Mollie acted so fearfully and aggressively that the veterinarian and her 3 assistants could not control Mollie long enough to muzzle her and administer the vaccination. The veterinarian gave Kathy Acepromazine in 25 mg. pills and told Kathy that: Acepromazine is better than a sedative; it controls the dog's fear and aggression for 4 -- 6 hours; the recommended dosage is 1 1/2-2 pills to be administered 1 hour before Mollie's next veterinary visit; Kathy should try...

Within 5 minutes of eating the Acepromazine, Mollie began to stumble, then her legs collapsed beneath her and for nearly 5 hours, Mollie was wild-eyed but unable to move. Kathy immediately called the veterinarian, who calmly said to just give Mollie a lower dose of 1 pill before her next appointment. Kathy is still wary of Acepromazine because she saw its effect on Mollie, so she asked me to research this drug and find out why it had such an extreme effect.
Acepromazine is also called Promace® (Kelley), has a formula of C23H26N2O5S and is grouped in the drug categories of antipsychotic agents, dopamine antagonists,…